Title | Novel Therapeutic Targets for Autism |
Publication Type | Journal Article |
Authors | Theoharides TC, Doyle R, Francis K, Conti P, Kalogeromitros D |
Journal Title | Trends in Pharmacological Sciences |
Year of Publication | 2008 |
Volume | 29 |
Issue | 8 |
Pages | 375-382 |
URL for Abstract | http://www.ncbi.nlm.nih.gov/pubmed/18606459?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum |
Full Text | Some drugs that stop the allergic response of the immune system may be able to help with the symptoms of autism. This article presents the authors' view that autism is caused by problems in the immune cells of the gut and brain. The authors suggest that mast cells in the body release chemicals that affect gut and brain function. They further suggest that certain supplements (antioxidants) and drugs that block mast cells may be able to help people with autism. One such drug is cyproheptadine, which blocks histamine, which is released from mast cells, and blocks the brain chemical serotonin. Cromolyn is another drug that seems to be able to stop mast cells and may help with some of the symptoms of autism. The authors also propose the therapeutic use of SAMe (S-adenosylmethionine), which is an antioxidantsupplement. |
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Novel Therapeutic Targets for Autism
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